0
[文章]

【客户文章】2019- EBioMedicin-代谢物的变化对肠道菌群的影响

代谢组学专题微生态专题

Alteration of gut microbiota induced by DPP-4i treatment improves

glucose homeostasis

 

EBioMedicine, IF = 6.183

 

文献摘要:

Methods: 16S-rDNA sequencing was performed to analyse the effects of DPP-4i and acarbose on the gut microbiota in mice fed a high-fat diet (HFD). Fecal microbiota transplantation (FMT) from type 2 diabetes patients to germ-free mice was performed to investigate the contribution of the altered microbiome to antidiabetic effects of the drugs. Fecal metabolomics was also analysed by untargeted and targeted GC–MS systems.

Findings: Although DPP-4i and α-glucosidase inhibitor both altered the gut microbial composition, only the microbiome modulation of DPP-4i contributed to its hypoglycemic effect. Specifically, the changes of 68.6% genera induced by HFD were rescued by DPP-4i. FMT showed that the DPP-4i-altered microbiome improved glucose tolerance in colonized mice, while acarbose did not. Moreover, DPP-4i increased the abundance of Bacteroidetes, and also promoted a functional shift in the gut microbiome, especially increasing the production of succinate.Interpretation: Our findings demonstrate an important effect of DPP-4i on the gut microbiota, revealing a new hypoglycemic mechanism and an additional benefit of it. Furthermore, modulating the microbial composition, and the functional shift arising from changes in the microbiome, might be a potential strategy for improving glucose

homeostasis.

 

主要结果:


参考文献:

XY Lin , LY Song, BH Zeng, et al., Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis. EBioMedicine (2019), doi.org/10.1016/j.ebiom.2019.03.057.




今天叫一 2019-11-04 16:04:46

0个评论

    暂时还没有评论!

热门话题